This article from the Healthcare Information and Management Systems Society (HIMSS) blog is the second of a three-part posting concerning the establishment of an HIE, particularly for patients who are deemed vulnerable due to lack of regular access to the healthcare delivery system and the presence of one or more chronic diseases. It starts with the essential questions of who will be using the data and for what purpose(s). It continues on with the question of how (question format and gathering mechanism) and the need to standardize the data in order to maximize the utility of the overall dataset. Finally, it suggests the where (data gathering venues) that would be appropriate for the vulnerable population under consideration.